According to a new research, taking aspirin increases the risk of heart failure by 26 percent. Other factors associated with this are smoking, obesity, high blood pressure, high cholesterol, diabetes and heart disease. The findings of this research have been published in the journal ESC Heart Failure. Study author Dr. Blerim Mujaz, from the University of Illinois, said this is the first study to report that individuals taking aspirin with at least one risk factor for heart failure had a later condition than those not using the drug. more likely to develop. While the findings need confirmation, they indicate that the potential link between aspirin and heart failure needs to be clarified. The effect of aspirin on heart failure is controversial. The aim of this study is to evaluate its relationship with the incidence of heart failure in people with and without heart disease to determine whether drug use is related to a new diagnosis of heart failure in people at risk. The analysis included 30,827 individuals at risk of developing heart failure who were enrolled in the HOMAGE study from Western Europe and the Americas. (aspirin effect heart)
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Aspirin reduces heart risk to 25%
At-risk was defined as one or more of the following: smoking, obesity, high blood pressure, high cholesterol, diabetes and heart disease. Participants were 40 years of age and older and were free of heart failure at baseline. Aspirin use was recorded at enrollment and participants were classified as user or non-user. Participants were followed for the first occurrence of fatal or nonfatal heart failure requiring hospitalization. The mean age of the participants was 67 years and 34 percent were female. At baseline, a total of 7,698 participants (25 percent) were taking aspirin. During a 5.3-year follow-up, 1,330 participants had developed heart failure. The investigators measured the use of aspirin and the incidence of heart failure after adjusting for gender, age, body mass index, smoking, alcohol use, blood pressure, heart rate, blood cholesterol, creatinine, hypertension, diabetes, cardiovascular disease and renin treatment. assessed the relationship between Angiotensin-aldosterone-system inhibitors, calcium channel blockers, diuretics, beta-blockers and lipid-lowering drugs.
Aspirin use linked to heart failure
Taking aspirin was independently associated with a 26 percent increased risk of a new heart failure diagnosis. To examine the consistency of the results, the researchers repeated the analysis after matching aspirin users and non-users for heart failure risk factors. In this matched analysis, aspirin was associated with a 26 percent increased risk of a new heart failure diagnosis. To further examine the results, the analysis was repeated after excluding patients with a history of cardiovascular disease. In 22,690 participants (74 percent) free of heart disease, aspirin use had a 27 percent increased risk of heart failure. Dr Mujaz said this was the first large study to examine the relationship between aspirin use and incident heart failure and at least one risk factor in individuals with and without heart disease. Aspirin is commonly used – one in four participants in our study was taking the drug. Aspirin use in this population was associated with the incidence of heart failure, independent of other risk factors. They concluded that larger multinational randomized trials in adults at risk of heart failure are needed to verify these results. Until then, our observations suggest that aspirin should be prescribed with caution in people with heart failure or with risk factors for the condition. (aspirin effect heart)